Article

The Origins and Consequences of Localized and Global Somatic Hypermutation

2018-03-23

Abstract excerpt

Cancer is a disease of the genome, but the dramatic inter-patient variability in mutation number is poorly understood. Tumours of the same type can differ by orders of magnitude in their mutation rate. To understand potential drivers and consequences of the underlying heterogeneity in mutation rate across tumours, we evaluated both local and global measures of mutation density: both single-stranded and double-stra...

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Literature Corpus work: 232604cb-ddab-5eba-bd52-39562d85693b
DOI: 10.1101/287839

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