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Article

Katdetectr: an R/bioconductor package utilizing unsupervised changepoint analysis for robust kataegis detection.

GigaScience - 28 Dec 2022

Hazelaar Daan M, van Riet Job, Hoogstrate Youri, van de Werken Harmen J G

Abstract excerpt

BACKGROUND: Kataegis refers to the occurrence of regional genomic hypermutation in cancer and is a phenomenon that has been observed in a wide range of malignancies. A kataegis locus constitutes a genomic region with a high mutation rate (i.e., a higher frequency of closely interspersed somatic variants than the overall mutational background). It has been shown that kataegis is of biological significance and...

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Identifiers

PMID: 37848617
DOI: 10.1093/gigascience/giad081
PMCID: PMC10580377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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