Article

Katdetectr: An R/Bioconductor package utilizing unsupervised changepoint analysis for robust kataegis detection

2022-07-11

Abstract excerpt

<h4>Background</h4> Kataegis refers to the occurrence of regional genomic hypermutation in cancer and is a phenomenon that has been observed in a wide range of malignancies. A kataegis locus constitutes a genomic region with a high mutation rate, i.e., a higher frequency of closely interspersed somatic variants than the overall mutational background. It has been shown that kataegis is of biological significance a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 650596c5-955a-52d4-b2d1-797af5bc86da
DOI: 10.1101/2022.07.11.499364

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Katdetectr: An R/Bioconductor package utilizing unsupervised changepoint analysis for robust kataegis detectionDOI 10.1101/2022.07.11.499364Read

Katdetectr: an R/bioconductor package utilizing unsupervised changepoint analysis for robust kataegis detection.Semantic proximity Read

kataegis: an R package for identification and visualization of the genomic localized hypermutation regions using high-throughput sequencing.Semantic proximity Read

Kataegis in clinical and molecular subgroups of primary breast cancerSemantic proximity Read

CANCERSIGN: a user-friendly and robust tool for identification and classification of mutational signatures and patterns in cancer genomesSemantic proximity Read

Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGeneratorSemantic proximity Read

Genome-wide hyper-mutated genes and hotspot detection across 27 cancersSemantic proximity Read

CANCERSIGN: a user-friendly and robust tool for identification and classification of mutational signatures and patterns in cancer genomes.Semantic proximity Read

Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator.Semantic proximity Read

MesKit: a tool kit for dissecting cancer evolution of multi-region tumor biopsies through somatic alterations.Semantic proximity Read

MutSpot: detection of non-coding mutation hotspots in cancer genomesSemantic proximity Read

Regional Mutational Signature Activities in Cancer GenomesSemantic proximity Read

A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes.Semantic proximity Read