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Article

Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios.

eLife - 30 Mar 2020

Williams Marc J, Zapata Luis, Werner Benjamin, Barnes Chris P, Sottoriva Andrea, Graham Trevor A

Abstract excerpt

The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in somatic cells. However the link, in somatic evolution, between dN/dS values and fitness coefficients is missing. Here we present a quantitative model of somatic evolutionary dynamics that determines...

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Identifiers

PMID: 32223898
DOI: 10.7554/eLife.48714
PMCID: PMC7105384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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