Article
A general calculus of fitness landscapes finds genes under selection in cancers.
Genome research - 1 May 2022
Hsu Teng-Kuei, Asmussen Jennifer, Koire Amanda, Choi Byung-Kwon, Gadhikar Mayur A, Huh Eunna, Lin Chih-Hsu, Konecki Daniel M, Kim Young Won, Pickering Curtis R, Kimmel Marek, Donehower Lawrence A, Frederick Mitchell J, Myers Jeffrey N, Katsonis Panagiotis, Lichtarge Olivier
Abstract excerpt
Genetic variants drive the evolution of traits and diseases. We previously modeled these variants as small displacements in fitness landscapes and estimated their functional impact by differentiating the evolutionary relationship between genotype and phenotype. Conversely, here we integrate these derivatives to identify genes steering specific traits. Over cancer cohorts, integration identified 460 likely...
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