Article

Disease as a Mediator of Somatic Mutation - Lifespan Coevolution: Model Analysis and Empirical Tests

2025-02-07

Abstract excerpt

Multicellular organisms are confronted not only with germline mutations, but also with mutations emerging in somatic cells. Somatic mutations can lead to diverse pathologies, including cancer. Somatic mutation rate (SMR) can be constrained by evolved protection mechanisms, notably those repairing damaged DNA, or eliminating or slowing the growth of mutated cells. However, in a broader context, life history traits...

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Literature Corpus work: efb2391c-44e9-5002-832a-513f83fd9114
DOI: 10.1101/2025.02.05.636604

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