Article
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
2019-06-05
Abstract excerpt
The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in somatic cells, however the link, in somatic evolution, between dN/dS values and fitness coefficients is missing. Here we present a quantitative model of somatic evolutionary dynamics that yields the...
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Identifiers and source
- Literature Corpus work
- 05c49058-b8f7-5ab9-b99f-2f8587aedb0e
- DOI
- 10.1101/661264