Article

Mutation-Profile-Based Methods for Understanding Selection Forces in Cancer Somatic Mutations: A Comparative Analysis

2015-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Human genes exhibit different effects on fitness in cancer and normal cells. Here, we present an evolutionary approach to measure the selection pressure on human genes, using the well-known ratio of the nonsynonymous to synonymous substitution rate in both cancer genomes ( C N /C S ) and normal populations ( p N /p S ). A new mutation-profile-based method that adopts sample-specific mutati...

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Literature Corpus work: b55d592c-688e-59f9-9ded-a9cdc67e03c0
DOI: 10.1101/021147

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