Article

Interpreting <i>dN/dS</i> under different selective regimes in cancer evolution

2021-12-01

Abstract excerpt

The standard relationship between the dN/dS statistic and the selection coefficient is contingent upon the computation of the rate of fixation of non-synonymous and synonymous mutations among divergent lineages (substitutions). In cancer genomics, however, dN/dS is typically calculated by including mutations that are still segregating in the cell population. The interpretation of dN/dS within sexual populations...

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Literature Corpus work: db276e0b-0a9d-517d-b86e-379ccb09efd9
DOI: 10.1101/2021.11.30.470556

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