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Article

Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.

Nature genetics - 1 Jun 2020

Colom Bartomeu, Alcolea Maria P, Piedrafita Gabriel, Hall Michael W J, Wabik Agnieszka, Dentro Stefan C, Fowler Joanna C, Herms Albert, King Charlotte, Ong Swee Hoe, Sood Roshan K, Gerstung Moritz, Martincorena Inigo, Hall Benjamin A, Jones Philip H

Abstract excerpt

During aging, progenitor cells acquire mutations, which may generate clones that colonize the surrounding tissue. By middle age, normal human tissues, including the esophageal epithelium (EE), become a patchwork of mutant clones. Despite their relevance for understanding aging and cancer, the processes that underpin mutational selection in normal tissues remain poorly understood. Here, we investigated this issue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32424351
DOI: 10.1038/s41588-020-0624-3
PMCID: PMC7116672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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