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Article

The distribution of fitness effects of new mutations.

Nature reviews. Genetics - 1 Aug 2007

Eyre-Walker Adam, Keightley Peter D

Abstract excerpt

The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that has implications ranging from the genetic basis of complex disease to the stability of the molecular clock. It has been studied by two different approaches: mutation accumulation and mutagenesis experiments, and the analysis of DNA sequence data. The proportion of mutations that are advantageous, effectively...

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PMID: 17637733
DOI: 10.1038/nrg2146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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