Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cysteine 202 of cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection.

Cardiovascular research - 1 Jan 2021

Amanakis Georgios, Sun Junhui, Fergusson Maria M, McGinty Shane, Liu Chengyu, Molkentin Jeffery D, Murphy Elizabeth

Abstract excerpt

AIMS: Cyclophilin-D is a well-known regulator of the mitochondrial permeability transition pore (PTP), the main effector of cardiac ischaemia/reperfusion injury. However, the binding of CypD to the PTP is poorly understood. Cysteine 202 (C202) of CypD is highly conserved among species and can undergo redox-sensitive post-translational modifications. We investigated whether C202 regulates the opening of PTP....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cysteine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria, Heart

Share to Myocardial Infarction

Share to Myocardial Reperfusion Injury

Share to Myocytes, Cardiac

Share to Oxidation-Reduction

Share to Protein Processing, Post-Translational

Source

Open in PubMed Open full text

Identifiers

PMID: 32129829
DOI: 10.1093/cvr/cvaa053
PMCID: PMC7797215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cysteine 202 of cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection.PMID 32129829Read ↗

Functional decorations: post-translational modifications and heart disease delineated by targeted proteomicsSemantic proximity Read ↗

Cyclophilin D: Knocking On Death’s DoorSemantic proximity Read ↗

Redox characterization of human cyclophilin D: identification of a new mammalian mitochondrial redox sensor?Semantic proximity Read ↗

Evidence for redox sensing by a human cardiac calcium channel.Semantic proximity Read ↗

Thiol dependent intramolecular locking of Orai1 channels.Semantic proximity Read ↗

Redox regulation of mitochondrial ATP synthase: implications for cardiac resynchronization therapy.Semantic proximity Read ↗

Txnip C247S mutation protects the heart against acute myocardial infarction.Semantic proximity Read ↗

Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.Semantic proximity Read ↗

Cyclophilin D induces necrotic core formation by promoting mitochondria-mediated macrophage apoptosis in advanced atherosclerotic lesionsSemantic proximity Read ↗

Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm.Semantic proximity Read ↗

Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.Semantic proximity Read ↗

Role of palmitoylation on the neuronal glycine transporter GlyT2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.