Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Txnip C247S mutation protects the heart against acute myocardial infarction.

Journal of molecular and cellular cardiology - 1 Jun 2021

Nakayama Yoshinobu, Mukai Nobuhiro, Wang Bing F, Yang Kristen, Patwari Parth, Kitsis Richard N, Yoshioka Jun

Abstract excerpt

RATIONALE: Thioredoxin-interacting protein (Txnip) is a novel molecular target with translational potential in diverse human diseases. Txnip has several established cellular actions including binding to thioredoxin, a scavenger of reactive oxygen species (ROS). It has been long recognized from in vitro evidence that Txnip forms a disulfide bridge through cysteine 247 (C247) with reduced thioredoxin to inhibit the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Resistance
Share to Electrocardiography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Hypoxia-Inducible Factor 1

Share to Myocardial Infarction

Share to Organ Specificity

Share to Thioredoxins

Share to Ubiquitin Thiolesterase

Source

Open in PubMed Open full text

Identifiers

PMID: 33652022
DOI: 10.1016/j.yjmcc.2021.02.013
PMCID: PMC8154746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Txnip C247S mutation protects the heart against acute myocardial infarction.PMID 33652022Read ↗

Cardiomyocyte-specific Txnip C247S mutation improves left ventricular functional reserve in streptozotocin-induced diabetic mice.Semantic proximity Read ↗

Mutations in the Txnip PPXY motifs protect against myocardial infarction despite enhanced protein stability.Semantic proximity Read ↗

TXNIP is a critical regulator of human cardiometabolic healthSemantic proximity Read ↗

miRNA-541-5p regulates myocardial ischemia–reperfusion injury by targeting ferroptosisSemantic proximity Read ↗

Inhibition of ubiquitin-specific protease 7 ameliorates ferroptosis-mediated myocardial infarction by contrasting oxidative stress: An in vitro and in vivo analysisSemantic proximity Read ↗

A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients.Semantic proximity Read ↗

Deletion of the ion channel <i>Trpm4</i> increases cardiac inflammatory markers and fibrosis after myocardial infarction in miceSemantic proximity Read ↗

Protein Phosphatase 2A Activation Attenuates Acute Myocardial Injury in Takotsubo Syndrome by Modulating Ferroptosis and Mitochondrial Injury in CardiomyocytesSemantic proximity Read ↗

Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2.Semantic proximity Read ↗

Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.Semantic proximity Read ↗

Mutation of a single cysteine in CaMKIIδ protects the heart from ischemia-reperfusion InjurySemantic proximity Read ↗

Cardiac Troponin I Directly Binds and Inhibits Mitochondrial ATP Synthase: a Noncanonical Role in the Post-Ischemic HeartSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.