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Article

Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm.

Journal of molecular and cellular cardiology - 1 Feb 2020

Que Yumei, Shu Xi, Wang Langtao, Hu Pingping, Wang Sai, Xiong Rui, Liu Jin, Chen Hao, Tong Xiaoyong

Abstract excerpt

Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) is vital to maintain intracellular calcium homeostasis. SERCA2 cysteine 674 (C674) is highly conservative and its irreversible oxidation is upregulated in human and mouse aortic aneurysms, especially in smooth muscle cells (SMCs). The contribution of SERCA2 and its redox C674 in the development of aortic aneurysm remains enigmatic. Objective: Our goal was...

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Identifiers

PMID: 32035136
DOI: 10.1016/j.yjmcc.2020.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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