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Article

Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

The Journal of biological chemistry - 13 May 2005

Basso Emy, Fante Lisa, Fowlkes Jonathan, Petronilli Valeria, Forte Michael A, Bernardi Paolo

Abstract excerpt

We have studied the properties of the permeability transition pore (PTP) in mitochondria from the liver of mice where the Ppif gene encoding for mitochondrial Cyclophilin D (CyP-D) had been inactivated. Mitochondria from Ppif-/- mice had no CyP-D and displayed a striking desensitization of the PTP to Ca2+, in that pore opening required about twice the Ca2+ load necessary to open the pore in strain-matched,...

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Identifiers

PMID: 15792954
DOI: 10.1074/jbc.C500089200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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