Article
Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.
International journal of molecular sciences - 10 Jul 2021
Li Ang, Li Xuejun, Yi Jianxun, Ma Jianjie, Zhou Jingsong
Abstract excerpt
Mitoflashes are spontaneous transients of the biosensor mt-cpYFP. In cardiomyocytes, mitoflashes are associated with the cyclophilin D (CypD) mediated opening of mitochondrial permeability transition pore (mPTP), while in skeletal muscle they are considered hallmarks of mitochondrial respiration burst under physiological conditions. Here, we evaluated the potential association between mitoflashes and the mPTP...
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