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Article

Cyclophilin D: Knocking On Death’s Door

7 Jun 2005

Abstract excerpt

Two recent genetic studies have identified a critical role for cyclophilin D, a component of the mitochondrial membrane permeability transition pore, in cell death induced by calcium, reactive oxygen species, and cardiac ischemia-reperfusion injury. Transgenic mice lacking cyclophilin D developed normally but showed reduced infarct size after coronary artery ligation and reperfusion. Cells from the knockout mice...

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Share to Cardiac Ischemia and Reperfusion
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PMID: 15942033
DOI: 10.1126/stke.2872005pe26

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