Article

Cyclophilin D induces necrotic core formation by promoting mitochondria-mediated macrophage apoptosis in advanced atherosclerotic lesions

2023-09-06

Abstract excerpt

<h4>Background</h4> In advanced atherosclerotic lesions, apoptotic cell death of plaque macrophages results in necrotic core formation and plaque vulnerability. Cyclophilin D (CypD) is a mitochondria-specific cyclophilin involved in the process of cell death after organ ischemia-reperfusion. However, the role of CypD in atherosclerosis, especially in necrotic core formation, is unknown. <h4>Methods</h4> To clari...

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Literature Corpus work: 50a22734-9c5c-5da9-990e-9352c104601f
DOI: 10.1101/2023.09.05.556288

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