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Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics

28 Feb 2013

Abstract excerpt

The more than 300 currently identified post-translational modifications (PTMs) provides great scope for subtle or dramatic alteration of protein structure and function. Furthermore, the rapid and transient nature of many PTMs allows efficient signal transmission in response to internal and environmental stimuli. PTMs are predominantly added by enzymes, and the enzymes responsible (such as kinases) are thus...

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PMID: 23445784
DOI: 10.1186/gm424

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