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Article

Thiol dependent intramolecular locking of Orai1 channels.

Scientific reports - 14 Sept 2016

Alansary Dalia, Schmidt Barbara, Dörr Kathrin, Bogeski Ivan, Rieger Heiko, Kless Achim, Niemeyer Barbara A

Abstract excerpt

Store-operated Ca(2+) entry mediated by STIM1-gated Orai1 channels is essential to activate immune cells and its inhibition or gain-of-function can lead to immune dysfunction and other pathologies. Reactive oxygen species interacting with cysteine residues can alter protein function. Pretreatment of the Ca(2+) selective Orai1 with the oxidant H2O2 reduces ICRAC with C195, distant to the pore, being its major...

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Source

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Identifiers

PMID: 27624281
DOI: 10.1038/srep33347
PMCID: PMC5022029

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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