Article
PathFinder: Bayesian inference of clone migration histories in cancer.
Bioinformatics (Oxford, England) - 30 Dec 2020
Kumar Sudhir, Chroni Antonia, Tamura Koichiro, Sanderford Maxwell, Oladeinde Olumide, Aly Vivian, Vu Tracy, Miura Sayaka
Abstract excerpt
SUMMARY: Metastases cause a vast majority of cancer morbidity and mortality. Metastatic clones are formed by dispersal of cancer cells to secondary tissues, and are not medically detected or visible until later stages of cancer development. Clone phylogenies within patients provide a means of tracing the otherwise inaccessible dynamic history of migrations of cancer cells. Here, we present a new Bayesian...
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