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Article

Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans.

BMC biology - 24 Feb 2020

Alexander-Floyd J, Haroon S, Ying M, Entezari A A, Jaeger C, Vermulst M, Gidalevitz T

Abstract excerpt

BACKGROUND: Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic networks amenable to intervention, the mechanisms by which they impact individual susceptibility to proteotoxicity are still largely unknown. RESULTS: We have...

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PMID: 32093691
DOI: 10.1186/s12915-020-0750-5
PMCID: PMC7038566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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