Article

<i>C. elegans</i> genetic background modifies the core transcriptional response in an α-synuclein model of Parkinson’s disease

2018-06-16

Abstract excerpt

Accumulation of protein aggregates is a major cause of Parkinson’s disease (PD), a progressive neurodegenerative condition that is one of the most common causes of dementia. Transgenic Caenorhabditis elegans worms expressing the human synaptic protein α-synuclein show inclusions of aggregated protein and replicate the defining pathological hallmarks of PD. It is however not known how PD progression and pathology...

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Literature Corpus work: 6687c5a2-3422-59b3-b634-8f853ec94693
DOI: 10.1101/348623

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