Article
Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease.
BMC biology - 30 Sept 2013
Gidalevitz Tali, Wang Ning, Deravaj Tanuja, Alexander-Floyd Jasmine, Morimoto Richard I
Abstract excerpt
BACKGROUND: Monogenic gain-of-function protein aggregation diseases, including Huntington's disease, exhibit substantial variability in age of onset, penetrance, and clinical symptoms, even between individuals with similar or identical mutations. This difference in phenotypic expression of proteotoxic mutations is proposed to be due, at least in part, to the variability in genetic background. To address this, we...
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