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Natural variants in <i>C. elegans atg-5</i> 3’UTR uncover divergent effects of autophagy on polyglutamine aggregation in different tissues

2019-06-13

Abstract excerpt

Diseases caused by protein misfolding and aggregation, in addition to cell selectivity, often exhibit variation among individuals in the age of onset, progression, and severity of disease. Genetic variation has been shown to contribute to such clinical variation. We have previously found that protein aggregation-related phenotypes in a model organism, C. elegans , can be modified by destabilizing polymorphisms in...

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Literature Corpus work
b4895fc8-c444-5076-9243-16f9c92a0b6c
DOI
10.1101/670042
Open publication

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Natural variants in <i>C. elegans atg-5</i> 3’UTR uncover divergent effects of autophagy on polyglutamine aggregation in different tissuesDOI 10.1101/670042
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