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Article

Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans.

Biochemical and biophysical research communications - 11 Apr 2008

Khan Liakot A, Yamanaka Tomoyuki, Nukina Nobuyuki

Abstract excerpt

Neuronal homeostasis requires a balance between anabolic and catabolic processes. Eukaryotic cells use two distinct systems for the degradation of unused proteins: the ubiquitin-proteasome system and the autophagic system. The autophagic system is also necessary for the degradation of bulk amounts of proteins and organelles. We have searched for new autophagy-related genes in the Caenorhabditis elegans genome and...

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PMID: 18261464
DOI: 10.1016/j.bbrc.2008.01.150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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