Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan

Abstract excerpt

The degradation of cellular components through autophagy is essential for longevity and healthy aging. However, autophagy function decreases with aging, contributing to age-related diseases. In this study, we characterized a small-molecule activator of autophagy called AA-20 that enhances autophagy and lipid droplet clearance in human cells and in the nematode Caenorhabditis elegans . AA-20 reduces polyglutamine...

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