Article
B6.Rag1 Knockout Mice Generated at the Jackson Laboratory in 2009 Show a Robust Wild-Type Hypertensive Phenotype in Response to Ang II (Angiotensin II).
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2020
Seniuk Anika, Thiele Jonas L, Stubbe Andra, Oser Philipp, Rosendahl Alva, Bode Marlies, Meyer-Schwesinger Catherine, Wenzel Ulrich O, Ehmke Heimo
Abstract excerpt
A key finding supporting a causal role of the immune system in the pathogenesis of hypertension is the observation that RAG1 knockout mice on a C57Bl/6J background (B6.Rag1-/-), which lack functional B and T cells, develop a much milder hypertensive response to Ang II (angiotensin II) than control C57Bl/6J mice. Here, we report that we never observed any Ang II resistance of B6.Rag1-/- mice purchased directly...
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