Article
Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2008
Gembardt Florian, Heringer-Walther Silvia, van Esch Joep H M, Sterner-Kock Anja, van Veghel Richard, Le Thu H, Garrelds Ingrid M, Coffman Thomas M, Danser A H Jan, Schultheiss Heinz-Peter, Walther Thomas
Abstract excerpt
Angiotensin II activates two distinct receptors, the angiotensin II receptors type 1 (AT(1)) and type 2 (AT(2)). In rodents, two AT(1) subtypes were identified (AT(1a) and AT(1b)). To determine receptor-specific functions and possible angiotensin II effects independent of its three known receptors we generated mice deficient in either one of the angiotensin II receptors, in two, or in all three (triple...
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