Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.

doi:10.1073/pnas.95.26.15496

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Article

Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998

Oliverio M I, Kim H S, Ito M, Le T, Audoly L, Best C F, Hiller S, Kluckman K, Maeda N, Smithies O, Coffman T M

Abstract excerpt

The classically recognized functions of the renin-angiotensin system are mediated by type 1 (AT1) angiotensin receptors. Whereas man possesses a single AT1 receptor, there are two AT1 receptor isoforms in rodents (AT1A and AT1B) that are products of separate genes (Agtr1a and Agtr1b). We have gen...

Topics

Adrenal Glands
Angiotensin II
Angiotensinogen
Animals
Atrophy
Blood Pressure
Crosses, Genetic
Epinephrine
Female
Growth
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kidney

Kidney Medulla

Male

Mice

Mice, Knockout

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 9860997
DOI: 10.1073/pnas.95.26.15496
PMCID: PMC28071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9860997-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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