Article
A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor.
Seminars in nephrology - 1 Sept 1997
Coffman T M
Abstract excerpt
The ability to create targeted mutations in the mouse genome using homologous recombination in embryonic stem cells (gene targeting) has proved to be an extremely useful experimental approach. Recently, mouse lines have been produced with targeted disruptions of various genes in the renin-angiotensin system, and studies of these animals have provided new insights into a well-studied physiological system. This...
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