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Article

Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice.

The Journal of clinical investigation - 1 Jul 2007

Billet Sandrine, Bardin Sabine, Verp Sonia, Baudrie Véronique, Michaud Annie, Conchon Sophie, Muffat-Joly Martine, Escoubet Brigitte, Souil Evelyne, Hamard Ghislaine, Bernstein Kenneth E, Gasc Jean Marie, Elghozi Jean-Luc, Corvol Pierre, Clauser Eric

Abstract excerpt

The role of the renin-angiotensin system has been investigated by overexpression or inactivation of its different genes in animals. However, there is no data concerning the effect of the constitutive activation of any component of the system. A knockin mouse model has been constructed with a gain-of-function mutant of the Ang II receptor, type 1A (AT(1A)), associating a constitutively activating mutation (N111S)...

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Identifiers

PMID: 17607364
DOI: 10.1172/JCI28764
PMCID: PMC1890996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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