Article
Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2007
Cayla Cécile, Todiras Mihail, Iliescu Radu, Saul Vera V, Gross Volkmar, Pilz Bernhard, Chai Guixuan, Merino Vanessa F, Pesquero João B, Baltatu Ovidiu C, Bader Michael
Abstract excerpt
Kinins play a central role in the modulation of cardiovascular function and in the pathophysiology of inflammation. These peptides mediate their effects by binding to two specific G-protein coupled receptors named B1 and B2. To evaluate the full functional relevance of the kallikrein-kinin system, we generated mice lacking both kinin receptors (B1B2-/-). Because of the close chromosomal position of both kinin...
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