Article
Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex.
American journal of physiology. Heart and circulatory physiology - 1 Apr 2010
Taherzadeh Zhila, VanBavel Ed, de Vos Judith, Matlung Hanke L, van Montfrans Gert, Brewster Lizzy M, Seghers Leonard, Quax Paul H A, Bakker Erik N T P
Abstract excerpt
Hypertension is associated with chronic vascular inflammation. We tested the hypothesis that the sensitivity to develop hypertension and vascular remodeling depends on the immunological background. Blood pressure, vascular remodeling, endothelial function, vascular architecture (number of collateral arteries), and expression of inflammatory cytokines were determined in mice that received N(G)-nitro-l-arginine...
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