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Article

Loss of Resistance to Angiotensin II-Induced Hypertension in the Jackson Laboratory Recombination-Activating Gene Null Mouse on the C57BL/6J Background.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2017

Ji Hong, Pai Amrita V, West Crystal A, Wu Xie, Speth Robert C, Sandberg Kathryn

Abstract excerpt

Resistance to angiotensin II (Ang II)-induced hypertension in T-cell-deficient male mice with a targeted mutation in the recombination-activating gene-1 (Rag1) on the C57BL/6J background (B6.Rag1-/- -M), which was reported by 5 independent laboratories including ours before 2015, has been lost. In mice purchased from Jackson Laboratory in 2015 and 2016, the time course and magnitude increase in mean arterial...

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Identifiers

PMID: 28438904
DOI: 10.1161/HYPERTENSIONAHA.117.09063
PMCID: PMC5426956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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