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Article

Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage.

American journal of physiology. Regulatory, integrative and comparative physiology - 15 Mar 2013

Mattson David L, Lund Hayley, Guo Chuanling, Rudemiller Nathan, Geurts Aron M, Jacob Howard

Abstract excerpt

Hypertension and renal damage in Dahl SS rats are associated with increased infiltrating immune cells in the kidney. To examine the role of infiltrating immune cells in this disease process, a zinc finger nuclease targeting bases 672-706 of recombination-activating gene 1 (Rag1) was injected into the pronucleus of Dahl SS (SS/JrHsdMcwi) strain embryos and implanted in pseudopregnant females. This strategy yielded...

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Source

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Identifiers

PMID: 23364523
DOI: 10.1152/ajpregu.00304.2012
PMCID: PMC3602820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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