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Article

Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology.

Cell reports - 4 Feb 2020

Mohebiany Alma Nazlie, Ramphal Nishada Shakunty, Karram Khalad, Di Liberto Giovanni, Novkovic Tanja, Klein Matthias, Marini Federico, Kreutzfeldt Mario, Härtner Franziska, Lacher Sonja Maria, Bopp Tobias, Mittmann Thomas, Merkler Doron, Waisman Ari

Abstract excerpt

Tumor-necrosis-factor-alpha-induced protein 3 (TNFAIP3), or A20, is a ubiquitin-modifying protein and negative regulator of canonical nuclear factor κB (NF-κB) signaling. Several single-nucleotide polymorphisms in TNFAIP3 are associated with autoimmune diseases, suggesting a role in tissue inflammation. While the role of A20 in peripheral immune cells has been well investigated, less is known about its role in...

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PMID: 32023471
DOI: 10.1016/j.celrep.2019.12.097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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