Article
Preserving immune homeostasis with A20.
Advances in immunology - 1 Jan 2020
Razani Bahram, Malynn Barbara A, Ma Averil
Abstract excerpt
A20/TNFAIP3 is a TNF induced gene that plays a profound role in preserving cellular and organismal homeostasis (Lee, et al., 2000; Opipari etal., 1990). This protein has been linked to multiple human diseases via genetic, epigenetic, and an emerging series of patients with mono-allelic coding mutations. Diverse cellular functions of this pleiotropically expressed protein include immune-suppressive,...
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