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Kv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology

2025-12-25

Abstract excerpt

<h4>ABSTRACT</h4> Inhibition of voltage-gated potassium channel Kv1.3 is a therapeutic strategy to curb microglia-mediated neuroinflammation in neurodegeneration, although the cellular and signaling mechanisms of disease-modification by Kv1.3 blockers are unclear. In this study, we delineate protective mechanisms of Kv1.3 blockade in a mouse model of Alzheimer’s disease (AD) pathology using comprehensive transcri...

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Literature Corpus work
0b3b4031-0848-5b94-b077-a761e418bacd
DOI
10.64898/2025.12.25.696456
Open publication

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Kv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathologyDOI 10.64898/2025.12.25.696456
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