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Article

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.

Biochemical Society transactions - 1 Aug 2011

Vereecke Lars, Beyaert Rudi, van Loo Geert

Abstract excerpt

A20 [also known as TNFAIP3 (tumour necrosis factor α-induced protein 3)] restricts and terminates inflammatory responses through modulation of the ubiquitination status of central components in NF-κB (nuclear factor κB), IRF3 (interferon regulatory factor 3) and apoptosis signalling cascades. The phenotype of mice with full or conditional A20 deletion illustrates that A20 expression is essential to prevent...

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Source

Identifiers

PMID: 21787353
DOI: 10.1042/BST0391086

Genes

TNFAIP3

Provenance

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Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.PMID 21787353Read ↗

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