Article

NF-κB as an Inducible Regulator of Inflammation in the Central Nervous System

2024-02-01

Abstract excerpt

The NF-κB (nuclear factor K-light-chain-enhancer of activated B cells) transcription factor family is critical for modulating the immune proinflammatory response throughout the body. During the resting state, inactive NF-κB is sequestered by IκB in the cytoplasm. Proteasomal degradation of IκB activates NF-κB, mediating its translocation into the nucleus to act as a nuclear transcription factor in the upregulation...

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Literature Corpus work: aa9c6196-dcfd-56f7-b1a5-ffdb8bab2020
DOI: 10.20944/preprints202402.0003.v1

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