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Article

Type I interferon pathway in CNS homeostasis and neurological disorders

18 May 2017

Abstract excerpt

Type I interferons (IFNs), IFN-α and IFN-β, represent the major effector cytokines of the host immune response against viruses and other intracellular pathogens. These cytokines are produced via activation of numerous pattern recognition receptors, including the Toll-like receptor signaling network, retinoic acid-inducible gene-1 (RIG-1), melanoma differentiation-associated protein-5 (MDA-5) and interferon...

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PMID: 28519900
DOI: 10.1002/glia.23154

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