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Altered Levels and Isoforms of Tau and Nuclear Membrane Invaginations in Huntington’s Disease

17 Jan 2020

Abstract excerpt

Since the early reports of neurofibrillary Tau pathology in brains of some Huntington's disease (HD) patients, mounting evidence of multiple alterations of Tau in HD brain tissue has emerged in recent years. Such Tau alterations range from increased total levels, imbalance of isoforms generated by alternative splicing (increased 4R-/3R-Tau ratio) or by post-translational modifications such as hyperphosphorylation...

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PMID: 32009905
DOI: 10.3389/fncel.2019.00574

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