Article
Huntington's disease is a four-repeat tauopathy with tau nuclear rods.
Nature medicine - 1 Aug 2014
Fernández-Nogales Marta, Cabrera Jorge R, Santos-Galindo María, Hoozemans Jeroen J M, Ferrer Isidro, Rozemuller Annemieke J M, Hernández Félix, Avila Jesús, Lucas José J
Abstract excerpt
An imbalance of tau isoforms containing either three or four microtubule-binding repeats causes frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) in families with intronic mutations in the MAPT gene. Here we report equivalent imbalances at the mRNA and protein levels and increased total tau levels in the brains of subjects with Huntington's disease (HD) together with rod-like tau...
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