Article

Therapeutics Advancement for Huntington Disease

2019-12-19

Abstract excerpt

Huntington disease (HD) is an autosomal dominantly inherited fatal neurodegenerative disease. It affects motor, cognitive and psychiatric functions, and ultimately leads to death. The pathology of the disease is due to an expansion of CAG repeats in exon 1 of the huntingtin gene on chromosome 4, which produces a mutant huntingtin protein (mhtt). HD patients manifest a typical phenotype of sporadic, rapid, involunt...

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Literature Corpus work: 6fffded8-a1fd-529d-9f34-fd9c6d3eece7
DOI: 10.20944/preprints201912.0261.v1

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