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Molecular Pathogenesis in Huntington’s Disease

1 Sept 2018

Abstract excerpt

Huntington's disease (HD) is a severe autosomal dominant neurodegenerative disorder characterized by a combination of motor, cognitive, and psychiatric symptoms, atrophy of the basal ganglia and the cerebral cortex, and inevitably progressive course resulting in death 5-20 years after manifestation of its symptoms. HD is caused by expansion of CAG repeats in the HTT gene, which leads to pathological elongation of...

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PMID: 30472941
DOI: 10.1134/s0006297918090043

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