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Article

Multiple pathways contribute to the pathogenesis of Huntington disease.

1 Jan 2006

Abstract excerpt

Huntington disease (HD) is caused by expansion of a polyglutamine (polyQ) domain in the protein known as huntingtin (htt), and the disease is characterized by selective neurodegeneration. Expansion of the polyQ domain is not exclusive to HD, but occurs in eight other inherited neurodegenerative disorders that show distinct neuropathology. Yet in spite of the clear genetic defects and associated neurodegeneration...

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PMID: 17173700
DOI: 10.1186/1750-1326-1-19

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