Article

Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers

2023-05-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Neuronal nuclei are normally smoothly surfaced. In Alzheimer’s disease (AD) and other tauopathies, though, they often develop invaginations. We investigated mechanisms and functional consequences of neuronal nuclear invagination in tauopathies. <h4>METHODS</h4> Nuclear invagination was assayed by immunofluorescence in brain, and in cultured neurons before and after extrac...

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Literature Corpus work: f40f579c-7dd7-54c0-a83c-45eeaa2d8f51
DOI: 10.1101/2023.05.08.539873

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