Article

Nuclear Tau modulates VGluT1 expression: a new function for Tau

2018-08-17

Abstract excerpt

<h4>Summary: </h4> Tau displacement from microtubules is the first step in the onset of tauopathies, and is followed by toxic protein aggregation. However, other non-canonical functions of Tau might have a role in these pathologies. Here, we demonstrate that a small amount of Tau localizes in the nuclear compartment and accumulates in both the soluble and DNA-bound fractions. We show that nuclear Tau regulates the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41b915d6-f623-5ba3-b052-0badebdbee6e
DOI: 10.1101/394312

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nuclear Tau modulates VGluT1 expression: a new function for TauDOI 10.1101/394312Read

Tau Modulates VGluT1 ExpressionSemantic proximity Read

Roles of tau protein in health and diseaseSemantic proximity Read

Tau: More than a microtubule‐binding protein in neuronsSemantic proximity Read

Molecular Mechanism of Nuclear Tau Accumulation and its Role in Protein SynthesisSemantic proximity Read

Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer’s DiseaseSemantic proximity Read

Altered Levels and Isoforms of Tau and Nuclear Membrane Invaginations in Huntington’s DiseaseSemantic proximity Read

Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelopeSemantic proximity Read

Tau alters global gene expression affecting chromatin in the early stages of Alzheimer’s diseaseSemantic proximity Read

A new function of microtubule-associated protein tau: involvement in chromosome stability.Semantic proximity Read

Tau splicing and the intricacies of dementiaSemantic proximity Read

The physiology and pathology of microtubule-associated protein tauSemantic proximity Read

Disruption of nuclear envelope integrity as a possible initiating event in tauopathiesSemantic proximity Read