Article
Murine Surf4 is essential for early embryonic development.
PloS one - 1 Jan 2020
Emmer Brian T, Lascuna Paul J, Tang Vi T, Kotnik Emilee N, Saunders Thomas L, Khoriaty Rami, Ginsburg David
Abstract excerpt
Newly synthesized proteins co-translationally inserted into the endoplasmic reticulum (ER) lumen may be recruited into anterograde transport vesicles by their association with specific cargo receptors. We recently identified a role for the cargo receptor SURF4 in facilitating the secretion of PCSK9 in cultured cells. To examine the function of SURF4 in vivo, we used CRISPR/Cas9-mediated gene editing to generate...
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